Journal article
Retinal hyperspectral imaging in mouse models of Parkinson’s disease and healthy aging
P Trlin, J Gong, KKN Tran, VHY Wong, PY Lee, A Hoang, D Zhao, LC Beauchamp, JKH Lim, A Metha, KJ Barnham, DI Finkelstein, BV Bui, P Bedggood, CTO Nguyen
Scientific Reports | Published : 2024
Abstract
Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s disease is another neurodegenerative disease where brain pathobiology such as alpha-synuclein and iron overaccumulation have been implicated in the retina. However, it remains unknown whether HSI is altered in in vivo models of Parkinson’s disease, whether it differs from healthy aging, and the mechanisms which drive these changes. To address this, we conducted HSI in two mouse models of Parkinson’s disease across different ages; an alpha-synuclein overaccumulation model (hA53T transgenic line M83, A53T) and an iron deposition model (Tau knock out, TauKO). In comp..
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Grants
Awarded by University of Melbourne
Funding Acknowledgements
The authors would like to thank Amelia Sedjahtera (Parkinson's Disease Laboratory, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3010, Victoria, Australia) for breeding and genotyping the A53T mice.